The acetone and the Skincerity formula were shown to be non-toxic in a United States FDA protocol study under research grants funded by the National Institutes of Health/National Institute of Arthritis and Musculoskeletal and Skin Diseases (SBIR No. 5R42AR44435). In another study performed in conjunction with the University of Texas Health Science Center in San Antonio, Texas, results demonstrate that acetone alone or present in a mixture of acetone/polymer coating is non-toxic and nonirritating to skin. The study was funded by the National Institutes of Health/National Institute of Aging (SBIR No. 2R44AG12881-0).